Investigating Tissue-Specific Abnormalities in Alzheimer's Disease with Multi-Shell Diffusion MRI.

ABSTRACT:

Background

Most studies using diffusion-weighted MRI (DW-MRI) in Alzheimer's disease (AD) have focused their analyses on white matter (WM) microstructural changes using the diffusion (kurtosis) tensor model. Although recent works have addressed some limitations of the tensor model, such as the representation of crossing fibers and partial volume effects with cerebrospinal fluid (CSF), the focus remains in modeling and analyzing the WM.

Objective

In this work, we present a brain analysis approach for DW-MRI that disentangles multiple tissue compartments as well as micro- and macroscopic effects to investigate differences between groups of subjects in the AD continuum and controls.

Methods

By means of the multi-tissue constrained spherical deconvolution of multi-shell D

SUBMITTER: Giraldo DL 

PROVIDER: S-EPMC9789487 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature