Transcriptional profiling of hepatocytes infected with the replicative form of the malaria parasite Plasmodium cynomolgi.

ABSTRACT:

Background

The zoonotic simian parasite Plasmodium cynomolgi develops into replicating schizonts and dormant hypnozoites during the infection of hepatocytes and is used as a model organism to study relapsing malaria. The transcriptional profiling of P. cynomolgi liver stages was previously reported and revealed many important biological features of the parasite but left out the host response to malaria infection.

Methods

Previously published RNA sequencing data were used to quantify the expression of host genes in rhesus macaque hepatocytes infected with P. cynomolgi in comparison to either cells from uninfected samples or uninfected bystander cells.

Results

Although the dataset could not be used to resolve the transcriptional profile of hypnozoite-infected hepatocyte

SUBMITTER: Mitchell G 

PROVIDER: S-EPMC9789591 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature