Metabolic engineering of Rhodotorula toruloides for resveratrol production.

ABSTRACT:

Background

Resveratrol is a plant-derived phenylpropanoid with diverse biological activities and pharmacological applications. Plant-based extraction could not satisfy ever-increasing market demand, while chemical synthesis is impeded by the existence of toxic impurities. Microbial production of resveratrol offers a promising alternative to plant- and chemical-based processes. The non-conventional oleaginous yeast Rhodotorula toruloides is a potential workhorse for the production of resveratrol that endowed with an efficient and intrinsic bifunctional phenylalanine/tyrosine ammonia-lyase (RtPAL) and malonyl-CoA pool, which may facilitate the resveratrol synthesis when properly rewired.

Results

Resveratrol showed substantial stability and would not affect the R. toruloides gr

SUBMITTER: Zhang M 

PROVIDER: S-EPMC9789595 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature