Increased HRD score in cisplatin resistant penile cancer cells.

ABSTRACT:

Background/introduction

Penile cancer is a rare disease in demand for new therapeutic options. Frequently used combination chemotherapy with 5 fluorouracil (5-FU) and cisplatin (CDDP) in patients with metastatic penile cancer mostly results in the development of acquired drug resistance. Availability of cell culture models with acquired resistance against standard therapy could help to understand molecular mechanisms underlying chemotherapy resistance and to identify candidate treatments for an efficient second line therapy.

Methods

We generated a cell line from a humanpapilloma virus (HPV) negative penile squamous cell carcinoma (UKF-PEC-1). This cell line was subject to chronic exposure to chemotherapy with CDDP and / or 5-FU to induce acquired resistance in the newly esta

SUBMITTER: Winkelmann R 

PROVIDER: S-EPMC9789628 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature