The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates.

ABSTRACT:

Background

Considering the high correlation between the functional decline in Alzheimer's disease (AD) and the propagation of aggregated tau protein, many research efforts are focused on determining the underlying molecular mechanisms of tau spreading. Heparan sulfate proteoglycans (HSPGs) were reported to mediate cellular uptake of tau aggregates. Specifically, the heparan sulfates (HS) sulfation plays a critical role in the interaction of HSPGs with aggregated tau. HS can be N-/2-O/6-O- or 3-O-sulfated, some of which have been reported to take part in the interaction with tau aggregates. However, the role of the 3-O sulfation remains enigmatic.

Results

Here, we studied the contribution of HS 3-O sulfation in the binding and cellular uptake of tau aggregates. We observed re

SUBMITTER: Ferreira A 

PROVIDER: S-EPMC9789671 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature