OPA1 supports mitochondrial dynamics and immune evasion to CD8⁺ T cell in lung adenocarcinoma.

ABSTRACT:

Background

Mitochondrial fusion and fission were identified to play key roles during multiple biology process. Thus, we aim to investigate the roles of OPA1 in mitochondria fusion and immune evasion of non-small cell lung cancer cells.

Methods

The transcriptional activation of genes related to mitochondrial dynamics was determined by using multi-omics data in lung adenocarcinoma (LUAD). We elucidated the molecular mechanism and roles of OPA1 promoting lung cancer through single-cell sequencing and molecular biological experiments.

Results

Here, we found that copy number amplification of OPA1 and MFN1 were co-occurring and synergistically activated in tumor epithelial cells in lung cancer tissues. Both of OPA1 and MFN1 were highly expressed

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9789695 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature