Gastrointestinal symptom severity and progression in systemic sclerosis.

ABSTRACT:

Objectives

To evaluate the severity and evolution of patient-reported gastrointestinal tract (GIT) symptoms in systemic sclerosis (SSc) patients, assess predictive factors for progression and determine the impact of standard of care treatment.

Methods

SSc patients from the Leiden and Oslo cohorts were included. We assessed clinical data and patient-reported GIT symptoms measured by the validated University of California, Los-Angeles Gastrointestinal-tract (UCLA-GIT) score at baseline and annually. GIT severity and progression was determined. Logistic regression was applied to identify risk factors associated with baseline GIT symptom severity. Linear mixed-effect models were applied to assess progression in GIT symptom burden and to identify predictive factors. We repeated a

SUBMITTER: van Leeuwen NM 

PROVIDER: S-EPMC9789747 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature