Gut metagenome profile of the Nunavik Inuit youth is distinct from industrial and non-industrial counterparts.

ABSTRACT: Comparative metagenomics studies have highlighted differences in microbiome community structure among human populations over diverse lifestyles and environments. With their unique environmental and historical backgrounds, Nunavik Inuit have a distinctive gut microbiome with undocumented health-related implications. Using shotgun metagenomics, we explored the taxonomic and functional structure of the gut microbiome from 275 Nunavik Inuit ranging from 16 to 30-year-old. Whole-metagenome analyses revealed that Nunavik Inuit youths have a more diverse microbiome than their non-industrialized and industrialized counterparts. A comparison of k-mer content illustrated the uniqueness of the Nunavik gut microbiome. Short-chain fatty acids producing species, and carbohydrates degradation pathways do

SUBMITTER: Abed JY 

PROVIDER: S-EPMC9790006 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature