Placental transcriptomic signatures of spontaneous preterm birth.

ABSTRACT:

Background

Spontaneous preterm birth accounts for most preterm births and leads to significant morbidity in the newborn and childhood period. This subtype of preterm birth represents an increasing proportion of all preterm births when compared with medically indicated preterm birth, yet it is understudied in omics analyses. The placenta is a key regulator of fetal and newborn health, and the placental transcriptome can provide insight into pathologic changes that lead to spontaneous preterm birth.

Objective

This analysis aimed to identify genes for which placental expression was associated with spontaneous preterm birth (including early preterm and late preterm birth).

Study design

The ECHO PATHWAYS consortium extracted RNA from placental samples collected from the Co

SUBMITTER: Paquette AG 

PROVIDER: S-EPMC9790028 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature