Identification of hepatocellular carcinoma subtypes based on PcG-related genes and biological relevance with cancer cells.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is an extensive heterogeneous disease where epigenetic factors contribute to its pathogenesis. Polycomb group (PcG) proteins are a group of subunits constituting various macro-molecular machines to regulate the epigenetic landscape, which contributes to cancer phenotype and has the potential to develop a molecular classification of HCC.

Results

Here, based on multi-omics data analysis of DNA methylation, mRNA expression, and copy number of PcG-related genes, we established an epigenetic classification system of HCC, which divides the HCC patients into two subgroups with significantly different outcomes. Comparing these two epigenetic subgroups, we identified different metabolic features, which were related to epigenetic regulation of

SUBMITTER: Fu Y 

PROVIDER: S-EPMC9790136 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature