Remission of peanut allergy is associated with rewiring of allergen-driven T helper 2-related gene networks.

ABSTRACT:

Background

The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes.

Methods

Using a systems biology approach, we examined gene co-expression network patterns in peanut-specific CD4⁺ T cell responses before and after probiotic and peanut oral immunotherapy in subjects enrolled in the PPOIT-001 randomized trial: Responders who attained remission (n = 16), placebo-treated who remained allergic (n = 16).

Results

Acquisition of re

SUBMITTER: Ashley SE 

PROVIDER: S-EPMC9790273 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature