Navigated laser and aflibercept versus aflibercept monotherapy in treatment-naive branch retinal vein occlusion: A 12-month randomized trial.

ABSTRACT:

Purpose

Angiostatic agents have proven effective in the treatment of macular oedema in patients with branch retinal vein occlusion (BRVO). However, treatment is inconvenient and expensive, and novel treatment regimens are warranted. We aimed to evaluate if combination treatment of navigated central retinal laser and aflibercept lowered the treatment burden in these patients.

Methods

Treatment-naïve patients with BRVO and macular oedema were included at two centres and randomized 1:1 to three monthly injections of 2.0 mg aflibercept with (Group A) or without (Group B) navigated central laser, followed by aflibercept as needed from month 4 through 12. Re-treatment need was evaluated, and secondary endpoints included functional and anatomical outcomes and safety evaluated by re

SUBMITTER: Frederiksen KH 

PROVIDER: S-EPMC9790367 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature