Periodontitis and cognitive impairment in older adults: The mediating role of mitochondrial dysfunction.

ABSTRACT:

Background

Increased attention has been focused on the associations of periodontal disease with the onset and progression of cognitive impairment. Although the associations are likely to be multifactorial, few studies have explored the role of mitochondrial dysfunction in the periodontitis-dementia link.

Methods

Cross-sectional data of 1,883 participants aged ≥60 years in the National Health and Nutrition Examination Survey 2011-2014 were analyzed. The following data were collected: 1) general information on sociodemographic, behavioral, and health-related factors; 2) periodontal status (mean attachment loss [AL] and mean probing depth [PD]); 3) mitochondrion-derived biomarker of mitochondrial dysfunction (blood sample concentration of methylmalonic acid [MMA]); 4) cognitive

SUBMITTER: Li A 

PROVIDER: S-EPMC9790481 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature