Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles.

ABSTRACT:

Background and aims

We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with cardiovascular disease (CVD) and genetic risk factors.

Approach and results

We analyzed serum metabolome from 1154 individuals with biopsy-proven NAFLD, and from four mouse models of NAFLD with impaired VLDL-triglyceride (TG) secretion, and one with normal VLDL-TG secretion. We identified three metabolic subtypes: A (47%), B (27%), and C (26%). Subtype A phenocopied the metabolome of mice with impaired VLDL-TG secretion; subtype C phenocopied the metabolome of mice with normal VLDL-TG; and subtype B showed an intermediate signature. The percent of patients with NASH and fibrosis was comparable among subtypes, although subt

SUBMITTER: Martinez-Arranz I 

PROVIDER: S-EPMC9790568 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature