Leukocyte redistribution as immunological biomarker of corticosteroid resistance in severe asthma.

ABSTRACT:

Background

Earlier studies have suggested that the leukocyte redistribution can be considered as an immunological marker of the clinical response to corticosteroids (CS), representing an easy measurable potential biomarker in severe asthma.

Objective

The aim of this study was to determinate the utility of the leukocyte redistribution as a biomarker of disease heterogeneity in patients with severe asthma and as a bioindicator of potential CS resistance.

Methods

We developed an unbiased clustering approach based on the clinical data and the flow cytometry results of peripheral blood leukocyte phenotypes of 142 patients with severe asthma before and after systemic CS administration.

Results

Based on the differences in the blood count eosinophils, neutrophils and l

SUBMITTER: Cardoso-Vigueros C 

PROVIDER: S-EPMC9790739 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature