Causality of telomere length associated with calcific aortic valvular stenosis: A Mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown that calcific aortic valve stenosis (CAVS) is associated with a shorter telomere length (TL). However, the results of observational studies are often influenced by confounding factors and reverse causal associations; it is unclear whether there is a causal relationship between TL and CAVS. This study aimed to investigate the causal relationship between TL and CAVS.

Materials and methods

Genome-wide association study (GWAS) data on TL (n = 472,174) and CAVS (n = 311,437) were used to assess the effect of TL on CAVS. All the participants were of European ancestry. Three Mendelian randomization (MR) methods, namely, MR-Egger, weighted median, and inverse variance weighted (IVW), were used to assess the potential causal e

SUBMITTER: Wang J 

PROVIDER: S-EPMC9790894 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature