Mendelian randomization study reveals a causal relationship between rheumatoid arthritis and risk for pre-eclampsia.

ABSTRACT:

Background

Epidemiological observational studies have investigated the relationship between rheumatoid arthritis(RA) and pre-eclampsia, but no consistent conclusions were obtained due to various limitations. Hence, we conducted a two-sample mendelian randomization analysis to evaluate the potential causal effect of RA on pre-eclampsia.

Methods

Summary-level statistics for RA were derived from a large-scale meta-analysis of datasets of genome-wide association studies(GWAS) which involved 14,361 cases and 43,923 controls. Moreover, summary statistics for pre-eclampsia or eclampsia were sourced from the Finn biobank which contained 3,903 cases and 114,735 controls. The inverse variance weighting (IVW) as well as other four effective methods including MR-Egger, weighted median,

SUBMITTER: Zhang D 

PROVIDER: S-EPMC9790901 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature