Central Irisin Signaling Is Required for Normal Timing of Puberty in Female Mice.

ABSTRACT: Timing of puberty requires exquisite coordination of genes, hormones, and brain circuitry. An increasing level of body adiposity, signaled to the brain via the fat-derived hormone leptin, is recognized as a major factor controlling puberty onset. However, it is clear that leptin is not the only metabolic cue regulating puberty, and that developmental regulation of this process also involves tissues other than adipose, with muscle development potentially playing a role in the timing of puberty. The proteolytic processing of fibronectin type 3 domain-containing protein 5 (FNDC5) releases a hormone, irisin. Irisin is primarily produced by muscle and is released into circulation, where levels increase dramatically as puberty approaches. We investigated the effects of a global deletion of the F

SUBMITTER: Decourt C 

PROVIDER: S-EPMC9791080 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature