A Systematic Review of Heterogeneity in Outcome Definition and Reporting in Localised Renal Cancer.

ABSTRACT:

Context

Outcomes in renal cell carcinoma (RCC) are reported inconsistently, with variability in definitions and measurement. Hence, it is difficult to compare intervention effectiveness and synthesise outcomes for systematic reviews and to create clinical practice guidelines. This uncertainty in the evidence makes it difficult to guide patient-clinician decision-making. One solution is a core outcome set (COS): an agreed minimum set of outcomes.

Objective

To describe outcome reporting, definitions, and measurement heterogeneity as the first stage in co-creating a COS for localised renal cancer.

Evidence acquisition

We systematically reviewed outcome reporting heterogeneity in effectiveness trials and observational studies in localised RCC. In total, 2822 studies (rand

SUBMITTER: Beyer K 

PROVIDER: S-EPMC9791121 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature