The deubiquitinase USP8 regulates ovarian cancer cell response to cisplatin by suppressing apoptosis.

ABSTRACT: The identification of therapeutic approaches to improve response to platinum-based therapies is an urgent need for ovarian carcinoma. Deubiquitinases are a large family of ubiquitin proteases implicated in a variety of cellular functions and may contribute to tumor aggressive features through regulation of processes such as proliferation and cell death. Among the subfamily of ubiquitin-specific peptidases, USP8 appears to be involved in modulation of cancer cell survival by still poorly understood mechanisms. Thus, we used ovarian carcinoma cells of different histotypes, including cisplatin-resistant variants with increased survival features to evaluate the efficacy of molecular targeting of USP8 as a strategy to overcome drug resistance/modulate cisplatin response. We performed biochemica

SUBMITTER: Corno C 

PROVIDER: S-EPMC9791127 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature