Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke.

ABSTRACT:

Background

Stroke is one of the most common neurological diseases in the world and is clinically manifested by transient or permanent brain dysfunction. It has a high mortality and disability rate, which severely affects people's health and diminishes the quality of life. However, there is no efficient treatment that can be considered curative and there are other less well-known theories of pathogenesis. Therefore, it is imperative to gain a full understanding of the pathophysiology of ischemia and to seek new therapeutic strategies.

Methods

We first examined Kir4.1 channel and myelin based protein (MBP) expression in brain tissues from acute ischemic patients by Western blotting. We then established a transient ischemic mouse model (tMCAO) to conduct molecular, cell biologi

SUBMITTER: Hong X 

PROVIDER: S-EPMC9791134 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature