Serum sphingolipid profiling as a novel biomarker for metabolic syndrome characterization.

ABSTRACT:

Background

Sphingolipids are components of cell membrane structure, but also circulate in serum and are essential mediators of many cellular functions. While ceramides have been proposed previously as a useful biomarker for cardiometabolic disease, the involvement of other sphingolipids is still controversial. The aim of this study was to investigate the cross-sectional association between blood sphingolipidomic profiles and metabolic syndrome (MetS) as well as other atherosclerotic risk factors in a large population-based study in the U.S.

Methods

Clinical data and serum sphingolipidomic profiling from 2,063 subjects who participated in the biomarker project of the Midlife in the United States (MIDUS) study were used.

Results

Consistent with previous reports, we foun

SUBMITTER: Berkowitz L 

PROVIDER: S-EPMC9791223 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature