Morphological analysis of cell distribution and network structure via gap junctions in swine corneal stroma.

ABSTRACT: Because of corneal transplantation limitations, there is a need for cornea-specific regenerative medicine. The development of such regenerative medicine has been delayed because of the complex and unique structure of the corneal stroma. Few studies have explored the corneal stroma cell distribution and cell types in vivo. This study investigated regional differences in morphological characteristics and distributions of corneal keratocytes and immunocompetent cells in the corneal stroma to clarify their functions and structural characteristics. The porcine eyeballs were subjected to light microscopy, transmission electron microscopy, scanning electron microscopy, and immunofluorescence staining analyses. Corneal cells were primarily located in the limbus, rather than the center of the corne

SUBMITTER: Hoshino N 

PROVIDER: S-EPMC9791234 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature