Cancer immune profiling unveils biomarkers, immunological pathways, and cell type score associated with glioblastoma patients' survival.

ABSTRACT:

Introduction

Glioblastoma (GBM), isocitrate dehydrogenase (IDH) wild-type (IDH ^wt), and grade 4 astrocytomas, IDH mutant (IDH ^mut), are the most common and aggressive primary malignant brain tumors in adults. A better understanding of the tumor immune microenvironment may provide new biomarkers and therapeutic opportunities.

Objectives

We aimed to evaluate the expression profile of 730 immuno-oncology-related genes in patients with IDH ^wt GBM and IDH ^mut tumors and identify prognostic biomarkers and a gene signature associated with patient survival.

Methods

RNA was isolated from formalin-fixed, paraffin-embedded sections of 99 tumor specimens from patients treated with standard thera

SUBMITTER: Moreno DA 

PROVIDER: S-EPMC9791289 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature