Association between FLT3-ITD and additional chromosomal abnormalities in the prognosis of acute promyelocytic leukemia.

ABSTRACT:

Objectives

Internal tandem duplications of the Fms-like tyrosine kinase 3 gene (FLT3-ITD) and additional chromosomal abnormalities (ACA) are prognostic factors in patients with acute promyelocytic leukemia (APL). This study aimed to determine the effect of the association between FLT3-ITD and ACA in the prognosis of APL.

Methods

This was a retrospective cohort study including 60 patients with APL treated with all-trans retinoic acid (ATRA) and chemotherapy. Five-year overall survival (OS) and progression-free survival (PFS) were analyzed in patient groups according to the presence of FLT3-ITD and ACA.

Results

FLT3-ITD was an independent adverse factor for 5-year PFS, and ACA was an independent adverse factor for 5-year OS. There were signif

SUBMITTER: Vu MP 

PROVIDER: S-EPMC9791292 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature