Measurement of microvascular cerebral blood volume changes over the cardiac cycle with ferumoxytol-enhanced T₂^* MRI.

ABSTRACT:

Purpose

This feasibility study investigates the non-invasive measurement of microvascular cerebral blood volume (BV) changes over the cardiac cycle using cardiac-gated, ferumoxytol-enhanced T2∗ MRI.

Methods

Institutional review board approval was obtained and all subjects provided written informed consent. Cardiac gated MR scans were prospectively acquired on a 3.0T scanner in 22 healthy subjects using T2∗ -weighted sequences with 2D-EPI and 3D spiral trajectories. Images were collected before and after the intravenous administration of 2 doses of ferumoxytol (1 mg FE/kg and 4 mg FE/kg). Cardiac cycle-induced R2∗ (1/ T2∗ ) changes (Δ R2∗ ) and BV changes (ΔBV) throughout the cardiac cycle in gray matter (GM) and white matter (WM) were quantified and differences assessed usin

SUBMITTER: Rivera-Rivera LA 

PROVIDER: S-EPMC9791370 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature