Utility of extended HPV genotyping for the triage of self-sampled HPV-positive women in a screen-and-treat strategy for cervical cancer prevention in Cameroon: a prospective study of diagnostic accuracy.

ABSTRACT:

Objective

To explore the utility of extended Human Papillomavirus (HPV) genotyping to detect cervical intraepithelial neoplasia grade 2 or more (CIN2+) in a 'screen-and-treat' strategy for HPV-positive women in low-resource settings.

Design

Prospective study of diagnostic accuracy.

Setting

The study took place in West Cameroon between September 2018 and March 2020.

Participants

2014 women were recruited. Asymptomatic, non-pregnant women aged 30-49 years without history of CIN treatment, anogenital cancer or hysterectomy were eligible.

Interventions

Participants performed self-sampling for HPV testing with GeneXpert followed by visual inspection with acetic acid and Lugol's iodine (VIA) triage before treatment if required.

Main outcome measures

Liq

SUBMITTER: Broquet C 

PROVIDER: S-EPMC9791451 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature