Distinct and redundant roles for zebrafish her genes during mineralization and craniofacial patterning.

ABSTRACT: The Notch pathway is a cell-cell communication system which is critical for many developmental processes, including craniofacial development. Notch receptor activation induces expression of several well-known canonical targets including those encoded by the hes and her genes in mammals and zebrafish, respectively. The function of these genes, individually and in combination, during craniofacial development is not well understood. Here, we used zebrafish genetics to investigate her9 and her6 gene function during craniofacial development. We found that her9 is required for osteoblasts to efficiently mineralize bone, while cartilage is largely unaffected. Strikingly, gene expression studies in her9 mutants indicate that although progenitor cells diffe

SUBMITTER: Stenzel A 

PROVIDER: S-EPMC9791542 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature