Prediction of protein stability changes upon single-point variant using 3D structure profile.

ABSTRACT: Identifying protein thermodynamic stability changes upon single-point variants is crucial for studying mutation-induced alterations in protein biophysics, genomic variants, and mutation-related diseases. In the last decade, various computational methods have been developed to predict the effects of single-point variants, but the prediction accuracy is still far from satisfactory for practical applications. Herein, we review approaches and tools for predicting stability changes upon the single-point variant. Most of these methods require tertiary protein structure as input to achieve reliable predictions. However, the availability of protein structures limits the immediate application of these tools. To improve the performance of a computational prediction from a protein sequence without ex

SUBMITTER: Gong J 

PROVIDER: S-EPMC9791599 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature