Modeling the Mechanical Microenvironment of Coiled Cerebral Aneurysms.

ABSTRACT: Successful occlusion of cerebral aneurysms using coil embolization is contingent upon stable thrombus formation, and the quality of the thrombus depends upon the biomechanical environment. The goal of this study was to investigate how coil embolization alters the mechanical micro-environment within the aneurysm dome. Inertialess particles were injected in three-dimensional, computational simulations of flow inside patient aneurysms using patient-specific boundary conditions. Coil embolization was simulated as a homogenous porous medium of known permeability and inertial constant. Lagrangian particle tracking was used to calculate the residence time and shear stress history for particles in the flow before and after treatment. The percentage of particles entering the aneurysm dome correlate

SUBMITTER: Bass DI 

PROVIDER: S-EPMC9791668 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature