Gut microbiota of the young ameliorates physical fitness of the aged in mice.

ABSTRACT:

Background

Aging is a natural process that an organism gradually loses its physical fitness and functionality. Great efforts have been made to understand and intervene in this deteriorating process. The gut microbiota affects host physiology, and dysbiosis of the microbial community often underlies the pathogenesis of host disorders. The commensal microbiota also changes with aging; however, the interplay between the microbiota and host aging remains largely unexplored. Here, we systematically examined the ameliorating effects of the gut microbiota derived from the young on the physiology and phenotypes of the aged.

Results

As the fecal microbiota was transplanted from young mice at 5 weeks after birth into 12-month-old ones, the thickness of the muscle fiber and grip streng

SUBMITTER: Kim KH 

PROVIDER: S-EPMC9791737 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature