Staphylococcus aureus populations from the gut and the blood are not distinguished by virulence traits-a critical role of host barrier integrity.

ABSTRACT:

Background

The opportunistic pathogen Staphylococcus aureus is an asymptomatically carried member of the microbiome of about one third of the human population at any given point in time. Body sites known to harbor S. aureus are the skin, nasopharynx, and gut. In particular, the mechanisms allowing S. aureus to pass the gut epithelial barrier and to invade the bloodstream were so far poorly understood. Therefore, the objective of our present study was to investigate the extent to which genetic differences between enteric S. aureus isolates and isolates that caused serious bloodstream infections contribute to the likelihood of invasive disease.

Results

Here, we present genome-wide association studies (GWAS) that compare the genome sequences of 69 S. aureus isolates from enteri

SUBMITTER: Raineri EJM 

PROVIDER: S-EPMC9791742 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature