Substance P promotes immunotherapy efficacy for airway allergy.

ABSTRACT:

Background

Allergen-specific immunotherapy (AIT) has been employed in the treatment of allergic diseases for many years. However, the effectiveness of AIT requires improvement. Substance P (SP) can interact with immune cells, modulate immune cell activity, and regulate immune reaction. The purpose of this study is to use SP as an immune regulator to enhance the therapeutic efficacy of AIT.

Methods

An established mouse model of the airway allergy disorder (AAD) was employed with ovalbumin as a specific antigen. The AAD response was evaluated through established procedures. AAD mice were treated with AIT employing SP as an immune regulator. Dendritic cells were isolated from the airway tissues by magnetic cell sorting, and were analyzed by RNA sequencing (RNAseq).

Results</

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9791926 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature