Dactylosporolides: Glycosylated Macrolides from Dactylosporangium fulvum.

ABSTRACT: A series of novel macrolides were discovered from the culture supernatant of the rare soil actinobacteria Dactylosporangium fulvum and named dactylosporolides A-C. The structure and absolute configuration of these dactylosporolides were defined using a combination of NMR structural elucidation and analysis of the dactylosporolide biosynthetic gene cluster. Together these data revealed dactylosporolides to be composed of a central 22-membered macrolactone with an internal hemiketal ring and a protruding ketide tail that were (poly)glycosylated at two distal parts. While bearing no antibiotic activity, these dactylosporolides displayed activity against Plasmodium falciparum 3D7.

SUBMITTER: Caradec T 

PROVIDER: S-EPMC9791991 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature