A novel prognostic signature of cuproptosis-related genes and the prognostic value of FDX1 in gliomas.

ABSTRACT: Background: Gliomas are the most common malignant tumors of the central nervous system, with extremely bad prognoses. Cuproptosis is a novel form of regulated cell death. The impact of cuproptosis-related genes on glioma development has not been reported. Methods: The TCGA, GTEx, and CGGA databases were used to retrieve transcriptomic expression data. We employed Cox's regressions to determine the associations between clinical factors and cuproptosis-related gene expression. Overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) were evaluated using the Kaplan-Meier method. We also used the least absolute shrinkage and selection operator (LASSO) regression technique. Results: The expression levels of all 10 CRGs varied considerably

SUBMITTER: Zhu H 

PROVIDER: S-EPMC9792093 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature