Small intestinal submucosa-derived extracellular matrix as a heterotopic scaffold for cardiovascular applications.

ABSTRACT: Structural cardiac lesions are often surgically repaired using prosthetic patches, which can be biological or synthetic. In the current clinical scenario, biological patches derived from the decellularization of a xenogeneic scaffold are gaining more interest as they maintain the natural architecture of the extracellular matrix (ECM) after the removal of the native cells and remnants. Once implanted in the host, these patches can induce tissue regeneration and repair, encouraging angiogenesis, migration, proliferation, and host cell differentiation. Lastly, decellularized xenogeneic patches undergo cell repopulation, thus reducing host immuno-mediated response against the graft and preventing device failure. Porcine small intestinal submucosa (pSIS) showed such properties in alternative cl

SUBMITTER: Palmosi T 

PROVIDER: S-EPMC9792098 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature