Longitudinal trajectory of acidosis and mortality in acute kidney injury requiring continuous renal replacement therapy.

ABSTRACT:

Background

Acidosis frequently occurs in severe acute kidney injury (AKI), and continuous renal replacement therapy (CRRT) can control this pathologic condition. Nevertheless, acidosis may be aggravated; thus, monitoring is essential after starting CRRT. Herein, we addressed the longitudinal trajectory of acidosis on CRRT and its relationship with worse outcomes.

Methods

The latent growth mixture model was applied to classify the trajectories of pH during the first 24 hours and those of C-reactive protein (CRP) after 24 hours on CRRT due to AKI (n = 1815). Cox proportional hazard models were used to calculate hazard ratios of all-cause mortality after adjusting multiple variables or matching their propensity scores.

Results

The patients could be classified into 5 clus

SUBMITTER: Lee J 

PROVIDER: S-EPMC9792158 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature