Impact of daily vitamin D₃ supplementation on the risk of vitamin D deficiency with the interaction of rs2282679 in vitamin D binding protein gene (GC) among overweight and obese children and adolescents: A one-year randomized controlled trial.

ABSTRACT:

Background

The rs2282679 polymorphism in the vitamin D binding protein (DBP) gene may influence the response to vitamin D supplementation. Therefore, we examine the effect of 1-year vitamin D supplementation on vitamin D deficiency (VDD) with the interaction of rs2282679 polymorphism in overweight and obese children and adolescents.

Materials and methods

The participants (n = 300) were part of a randomized controlled trial who received a daily supplement of either 1,000 or 2,000 IU or four supplements of 1,000 IU weekly (equal to 600 IU daily) of vitamin D₃ for 12 months. Genotyping was performed using amplification refractory mutation system polymerase chain reaction (ARMS-PCR).

Results

The mean of 25(OH)D values at baseline for participants with th

SUBMITTER: Asghari G 

PROVIDER: S-EPMC9792175 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature