The pattern and magnitude of T cell subsets reconstitution during ten years of ART with viral suppression in HIV-infected patients.

ABSTRACT:

Background

The extent of immune reconstitution in human immunodeficiency virus (HIV) infected persons receiving long-term antiretroviral therapy (ART) with controlled viral load has been controversial. We studied the extent and speed of T cell subsets retrieval after long-term antiretroviral treatment.

Methods

662 HIV-infected patients followed at least 2 years whose plasma HIV-1 RNA load <50 copies/mL were evaluated for longitudinal and functional phenotypic indices of immune restoration. Determinants of change in magnitude and importance of recovery have been evaluated using mixed linear regression models.

Results

Almost all robust immune restorations achieved occurred after 2-3 years of ART. The median CD4 lymphocyte count increased 449 cells/μl (IQR 303-604) from

SUBMITTER: Lu L 

PROVIDER: S-EPMC9792206 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature