DNA methylation-based measures of biological aging and cognitive decline over 16-years: preliminary longitudinal findings in midlife.

ABSTRACT: DNA methylation-based (DNAm) measures of biological aging associate with increased risk of morbidity and mortality, but their links with cognitive decline are less established. This study examined changes over a 16-year interval in epigenetic clocks (the traditional and principal components [PC]-based Horvath, Hannum, PhenoAge, GrimAge) and pace of aging measures (Dunedin PoAm, Dunedin PACE) in 48 midlife adults enrolled in the longitudinal arm of the Adult Health and Behavior project (56% Female, baseline Age_M = 44.7 years), selected for discrepant cognitive trajectories. Cognitive Decliners (N = 24) were selected based on declines in a composite score derived from neuropsychological tests and matched with participants who did not show any decline, Maintainers (N

SUBMITTER: Reed RG 

PROVIDER: S-EPMC9792211 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature