METTL14 Regulates Intestine Cellular Senescence through m⁶A Modification of Lamin B Receptor.

ABSTRACT: N-6-Methyladenosine (m⁶A) modification is involved in multiple biological processes including aging. However, the regulation of m⁶A methyltransferase-like 14 (METTL14) in aging remains unclear. Here, we revealed that the level of m⁶A modification and the expression of METTL14 were particularly decreased in the intestine of aged mice as compared to young mice. Similar results were confirmed in Drosophila melanogaster. Knockdown of Mettl14 in Drosophila resulted in a short lifespan, associated disrupted intestinal integrity, and reduced climbing ability. In human CCD-18Co cells, knockdown of METTL14 accelerated cellular senescence, and the overexpression of METTL14 rescued senescent phenotypes. We also identified the lamin B receptor (LBR) as a

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC9792243 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature