Diastolic heart failure is a new clinical entity of trastuzumab-induced cardiotoxicity: a case report.

ABSTRACT:

Background

Cancer therapy-related cardiac dysfunction (CTRCD) is defined as a decrease in the left ventricular ejection fraction (LVEF) of >10% to a value below the lower limit of normal or relative reduction in global longitudinal strain (GLS) >15% from baseline after cancer treatment. However, the possibility of the development of isolated diastolic dysfunction has never been considered in the clinical presentation of CTRCD.

Case summary

An 81-year-old woman was admitted to our institution presenting with prominent bilateral leg oedema, orthopnoea, and 8 kg of weight gain after administration of the anti-human epidermal growth factor receptor 2 (HER-2) antibody, trastuzumab, for HER-2-positive breast cancer. Transthoracic echocardiography showed a preserved LVEF of 62% wit

SUBMITTER: Fujita K 

PROVIDER: S-EPMC9792275 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature