Thyroid volume changes following adjuvant radiation therapy for breast cancer.

ABSTRACT:

Background and purpose

Incidental thyroid gland irradiation frequently occurs in breast cancer patients who receive regional nodal irradiation (RNI) to the supraclavicular (SCV) region. Recent studies suggest hypothyroidism (HT) is a complication of radiation therapy (RT) that includes SCV fields. We retrospectively analyzed patients who received RNI to evaluate thyroid gland evolution following RT as well as its association with the development of HT.

Materials and methods

61 breast cancer patients received SCV-directed RT between 2007 and 2019 and met inclusion criteria. Thyroid glands were retrospectively contoured on CT simulation and follow-up images. Individual dose-volume histograms were analyzed to determine thyroid volume within and outside specific isodose lines. R

SUBMITTER: Roberson J 

PROVIDER: S-EPMC9792369 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature