Childhood to adulthood: Accounting for age dependence in healthy-reference distributions in ¹²⁹ Xe gas-exchange MRI.

ABSTRACT:

Purpose

Xenon-129 (¹²⁹ Xe) gas-exchange MRI is a pulmonary-imaging technique that provides quantitative metrics for lung structure and function and is often compared to pulmonary-function tests. Unlike such tests, it does not normalize to predictive values based on demographic variables such as age. Many sites have alluded to an age dependence in gas-exchange metrics; however, a procedure for normalizing metrics has not yet been introduced.

Theory

We model healthy reference values for ¹²⁹ Xe gas-exchange MRI against age using generalized additive models for location, scale, and shape (GAMLSS). GAMLSS takes signal data from an aggregated heathy-reference cohort and fits a distribution with flexible median, variation, skewness, and kurtosis to predict age

SUBMITTER: Plummer JW 

PROVIDER: S-EPMC9792434 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature