Robust dual-module velocity-selective arterial spin labeling (dm-VSASL) with velocity-selective saturation and inversion.

ABSTRACT:

Purpose

Compared to conventional arterial spin labeling (ASL) methods, velocity-selective ASL (VSASL) is more sensitive to artifacts from eddy currents, diffusion attenuation, and motion. Background suppression is typically suboptimal in VSASL, especially of CSF. As a result, the temporal SNR and quantification accuracy of VSASL are compromised, hindering its application despite its advantage of being delay-insensitive.

Methods

A novel dual-module VSASL (dm-VSASL) strategy is developed to improve the SNR efficiency and the temporal SNR with a more balanced gradient configuration in the label/control image acquisition. This strategy applies for both VS saturation (VSS) and VS inversion (VSI) labeling. The dm-VSASL schemes were compared with single-module labeling and a previo

SUBMITTER: Guo J 

PROVIDER: S-EPMC9792445 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature