A pH-responsive T₁-T₂ dual-modal MRI contrast agent for cancer imaging.

ABSTRACT: Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO₂@MnO₂, which shows decreased T₁ and T₂ contrast intensity in normal physiological conditions. In the acid environment of tumor or inflamed tissue, the manganese dioxide (MnO₂) layer decomposes into magnetically active Mn²⁺ (T₁-weighted), and the T₁ and T₂ signals are sequentially recovered. In addition, both constrast quenching-activation degrees of T₁ and T₂ images can be accurately regulated by the silicon dioxide (SiO₂) intermediate layer between superparamagnetic iron

SUBMITTER: Lu H 

PROVIDER: S-EPMC9792454 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature