Effective natural inhibitors targeting granzyme B in rheumatoid arthritis by computational study.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is an autoimmune disease characterized by erosive arthritis, and current treatments for RA fall short of the outcomes expected by clinicians and patients.

Objectives

This study aimed to identify novel therapeutic and prognostic targets in RA at the genomic level and to screen desirable compounds with potential inhibitory effects on GZMB.

Methods

We performed differential gene analysis on GSE55235 and GSE55457 from Gene Expression Omnibus (GEO) and then obtained the intersection of the two differentially expressed genes (DEGs) lists by drawing Venn diagrams. Then we performed protein-protein interaction (PPI) network analysis, Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis on the DEGs of the

SUBMITTER: Wang X 

PROVIDER: S-EPMC9792495 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature