Effects of different applied voltages of irreversible electroporation on prostate cancer in a mouse model.

ABSTRACT: As a non-thermal ablation method, irreversible electroporation (IRE) has been widely investigated in the treatment of prostate cancer. However, no consensus has been achieved on the optimal parameters of IRE for prostate cancer. Since high voltage is known to carry risks of muscle contraction and patient discomfort, it is crucial to identify the minimum but effective and safer applied voltage to inhibit tumor growth. In this study, the effect of different applied voltages of IRE on prostate cancer was evaluated in BALB/c nude mice. Mathematical simulation and measurement of the actual ablation area revealed a larger ablation area at a higher voltage. In in vivo experiment, except for the three different voltages applied, all groups received identical electrical conditions: pulse number, 18

SUBMITTER: Kim HB 

PROVIDER: S-EPMC9792528 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature