A study of RNA m6A demethylases in oral epithelial dysplasia and oral squamous cell carcinoma.

ABSTRACT:

Purpose

N6-Methyladenosine (m6A) modification is involved in the tumorigenesis of various cancers. However, the roles of RNA m6A demethylases, fat mass and obesity-associated protein (FTO), and AlkB homolog 5 (ALKBH5) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) remain unclear. This study focuses on FTO and ALKBH5 expression by using immunohistochemistry.

Material and methods

Twenty specimens each of OED, OSCC, and normal oral mucosa (NOM) were included. The expression pattern, the number of positive cells, the cell-staining intensity, and the histochemical scoring (H-score) were examined and analyzed.

Results

In all the OED and OSCC specimens, FTO and ALKBH5 were mainly expressed with moderate to strong staining intensity in the nuclei o

SUBMITTER: Udompatanakorn C 

PROVIDER: S-EPMC9792536 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature