Prenatal and early childhood critical windows for the association of nephrotoxic metal and metalloid mixtures with kidney function.

ABSTRACT:

Introduction

As renal development and maturation processes begin in utero and continue through early childhood, sensitive developmental periods arise during which metal exposures can program subclinical nephrotoxicity that manifests later in life. We used novel dentine biomarkers of established nephrotoxicants including arsenic (As), cadmium (Cd), lead (Pb), chromium (Cr), and lithium (Li), and their mixtures, to identify critical windows of exposure-associated kidney function alterations in preadolescents.

Methods

Participants included 353 children in the Programming Research in Obesity Growth, Environment and Social Stressors (PROGRESS) longitudinal birth cohort study based in Mexico City. Estimated glomerular filtration rate (eGFR) was assessed in 8-12 year old children u

SUBMITTER: Sanders AP 

PROVIDER: S-EPMC9792626 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature